Cranberry + D-Mannose Capsules

This is a two-actives capsule rather than a single ingredient, and the two actives are chemically unrelated. One is a standardised fruit extract of the American cranberry, Vaccinium macrocarpon Aiton (Ericaceae), dosed on its proanthocyanidin assay and supplied as a deep red, markedly hygroscopic powder. The other is D-mannose, a simple sugar: an aldohexose of CAS 3458-28-4, C6H12O6, 180.16 g/mol, and the C-2 epimer of D-glucose, supplied as a white, freely water-soluble crystalline powder. D-mannose is normally the bulk of the fill and therefore sets the capsule size, while the cranberry extract is the component that carries the specification risk. The standard shell is HPMC, which keeps the finished capsule vegan; bovine or fish gelatin is available on request, with the shell material and its animal origin stated on the finished-product specification rather than left to the buyer to infer. The cranberry side is written tightly because this is where specifications routinely go wrong. Proanthocyanidins are reported by the DMAC colorimetric assay under AOAC Official Method 2019.06, and the certificate names the calibration standard, because procyanidin A2 and cranberry c-PAC do not return the same figure for the same extract. Folin and generic UV polyphenol numbers are not PAC values and read far higher; a bare percentage with no named method and no named standard is not comparable between suppliers and should not be accepted at purchase. The trade formulates to 36 mg of PAC per daily serving, which works out at 240 mg of a 15 per cent DMAC extract or 144 mg of a 25 per cent extract. A-type interflavan character is confirmed by MALDI-TOF MS along the lines of AOAC First Action Method 2019.05. Grape seed, which is B-type, and peanut skin, which is A-type and a peanut allergen, are both documented PAC adulterants, so every cranberry lot is profiled and peanut-free status is verified rather than merely attested — an important point given that published surveys have found a substantial share of commercial cranberry extracts and finished supplements differing from authentic fruit. On regulation, buyers should plan artwork before they plan volumes. US GRAS notice GRN 873 covers cranberry extract powder. In the EU, Article 13(1) claims that cranberry juice supports the urinary system are recorded in the register of nutrition and health claims as non-authorised, and an Article 14(1)(a) disease-risk-reduction claim submitted for a food supplement containing cranberry extract and D-mannose was assessed and not authorised either. Thovek therefore describes this product by composition and assay only and makes no therapeutic or disease representation of any kind; what may lawfully appear on a label is a matter for the buyer's regulatory team in the destination market, and the novel-food or permitted-ingredient status of D-mannose should be confirmed there before launch. No third-party branded cranberry ingredient is supplied, referenced or implied — the material is specified on its own DMAC figure. Both actives are hygroscopic, so capsules are blistered or bottled with desiccant, and each shipment carries the batch certificate of analysis, allergen and diet declarations, heavy-metal, pesticide and microbiological data, with halal, kosher and organic certification where the supply chain supports it.