L-Serine

L-Serine

L-Serine · C3H7NO3

Fermentation-derived L-Serine powder, CAS 56-45-1, assayed 98.5-101.0% on the dried basis. Non-animal, allergen-free crystalline amino acid for nutrition and cosmetic formulation.

Specifications

Chemical nameL-Serine; (2S)-2-amino-3-hydroxypropanoic acid
CAS number56-45-1
Molecular formula / weightC3H7NO3 / 105.09 g/mol
AppearanceWhite to off-white crystalline powder or crystals, odourless with a faintly sweet taste; melts with decomposition at approximately 228 deg C
Assay (dried basis)98.5 - 101.0 % C3H7NO3 by titration, to the Ph. Eur. and USP monograph range
Specific optical rotation+13.6 deg to +16.0 deg, calculated on the dried substance, measured in dilute hydrochloric acid per Ph. Eur. conditions
SolubilityFreely soluble in water, approximately 425 g/L at 25 deg C; practically insoluble in ethanol and diethyl ether
Loss on drying / residue on ignitionControlled to the Ph. Eur. and USP monograph limits; the measured value for each lot is stated on the batch CoA
Elemental impuritiesLead, arsenic, cadmium and mercury tested against ICH Q3D and monograph limits; results reported per batch
Source and production routeMicrobial fermentation of plant-derived glucose, or enzymatic synthesis from glycine and methanol; no animal-origin raw material used
Allergen statusFree from milk, egg, soy, fish, crustacean, gluten, peanut and tree nut; not produced from silk sericin or any animal protein hydrolysate
Dietary and origin suitabilityVegan and vegetarian suitable; non-bovine, non-porcine and non-marine. Non-GMO declaration, Kosher and Halal certificates available on request
Shelf life and storageTypically 24 - 36 months from manufacture in unopened original packing; store below 25 deg C, dry and out of direct sunlight
HS code (India)2922 50 90 - other amino-compounds with oxygen function; see classification note
L-Serine is the L-enantiomer of 2-amino-3-hydroxypropanoic acid, CAS 56-45-1, molecular formula C3H7NO3 and molecular weight 105.09. It is a small, uncharged polar proteinogenic amino acid that carries a primary hydroxyl group on its side chain, and that hydroxyl is what distinguishes it commercially and analytically from the simpler aliphatic amino acids: it makes the molecule freely water soluble at roughly 425 g/L at 25 degrees C, it gives L-Serine its characteristic dextrorotatory rotation of +13.6 to +16.0 degrees on the dried basis, and it is also the reason the material classifies away from the ordinary amino acid tariff lines. Thovek supplies the material as a white to off-white crystalline powder held to the Ph. Eur. and USP content range of 98.5 to 101.0 percent on the dried substance, with identity confirmed by infrared absorption and by optical rotation against a reference standard. Biochemically, L-Serine is dietarily non-essential in humans, meaning it is formed endogenously from 3-phosphoglycerate through the phosphorylated pathway rather than being required from food. In intermediary metabolism it is the principal donor of one-carbon units to the folate pool through serine hydroxymethyltransferase, and it is the backbone from which phosphatidylserine and the sphingoid bases are assembled, which is why formulators handle it as a precursor material rather than as a bulk protein filler. This is a description of composition and established metabolic function only; Thovek makes no therapeutic or disease claim for the ingredient, and finished-product claims remain the responsibility of the brand owner under the rules of the destination market. Origin is a live commercial question with this particular amino acid, because the Ph. Eur. monograph permits L-Serine obtained either by fermentation or by protein hydrolysis, and the historical hydrolysis route runs on silk sericin, which is an insect-derived protein. Thovek supplies only material made by microbial fermentation of plant-derived glucose or by enzymatic synthesis from glycine and methanol, so the product is vegan and vegetarian suitable and carries no animal, bovine, porcine or marine input. It is free from milk, egg, soy, fish, crustacean, gluten, peanut and tree nut. Buyers cross-referencing offers from other sources should confirm the route explicitly, since a hydrolysate-derived lot would change the vegan and allergen declaration on their own label. Full documentation travels with every shipment: batch CoA, MSDS, allergen and origin statement, non-GMO declaration, and Kosher and Halal certificates where required.

Applications

Free-form amino acid blendsSports nutrition powdersClinical and enteral nutritionPhosphatidylserine raw materialCell culture media componentCosmetic humectant formulationsCapsule and sachet fillsPharmaceutical intermediate synthesis

Available grades

Food grade (FCC), pharmaceutical grade to Ph. Eur. / USP / BP monograph, and cosmetic grade (INCI: Serine). Standard mesh is a free-flowing crystalline powder; granular and fine-milled cuts available to order. Non-GMO, Kosher and Halal certified lots on request.

Packaging: 25 kg fibre drums or multi-wall paper sacks with food-grade LDPE inner liner, heat sealed. 1 kg and 5 kg aluminium foil pouches for pilot and R&D quantities. Palletised and shrink-wrapped for FCL or LCL export; sample quantities of 100 g to 1 kg available against CoA.

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