Vitamin K1 (Phylloquinone)

Vitamin K1, known pharmacopoeially as phytonadione (USP) or phytomenadione (Ph Eur/BP), is the 2-methyl-3-phytyl-1,4-naphthoquinone form of vitamin K, CAS 84-80-0, molecular formula C31H46O2, molecular weight 450.70. In the body it acts as the cofactor for gamma-glutamyl carboxylase, the enzyme that carboxylates glutamate residues on vitamin K-dependent Gla proteins, including the coagulation factors II, VII, IX and X and the bone protein osteocalcin. Commercial material is produced by chemical synthesis and exists as a mixture of E (trans) and Z (cis) isomers; USP requires 97.0–103.0% of total C31H46O2 with not more than 21.0% Z-isomer, while the Ph Eur/BP monograph for phytomenadione requires not less than 75.0% of the trans isomer. We supply vitamin K1 in two commercial presentations. The neat oil is a clear yellow to amber, very viscous liquid with a refractive index of 1.523–1.526 at 25 °C and a relative density of about 0.967; it is practically insoluble in water, sparingly soluble in ethanol (96%) and miscible with fatty oils, which makes it directly usable in softgel fills, oil-based emulsions and lipid premixes. For dry blending we offer 1% and 5% cold-water-dispersible and spray-dried powders in which the oil is encapsulated on a modified starch, acacia or maltodextrin matrix, giving a free-flowing yellow powder suitable for direct compression, sachet blends and beverage fortification. Both forms are light-sensitive and are handled, filled and packed under nitrogen with light protection. Each batch is released against an in-house certificate of analysis covering HPLC assay and isomer ratio, appearance, refractive index or loss on drying as applicable, residual solvents, heavy metals (lead, arsenic, cadmium, mercury) and microbiological limits, with third-party verification available on request. Documentation supplied with export shipments includes the CoA, MSDS, allergen, GMO, BSE/TSE and nitrosamine declarations, and a stability/retest statement. Material is despatched from India with the export packing described below, under temperature-controlled conditions where the buyer's destination and transit time require it.